Pneumocystis jirovecii is a transmissible unicellular eukaryotic organism genetically belonging to the fungal kingdom. P. jirovecii is the causative agent of Pneumocystis pneumonia (PCP), a disease of particular concern for people with weakened cellular immune systems. Exposure to P. jirovecii occurs very early in life in infancy, leading to the detection of antibodies to P. jirovecii in 85% of healthy children at 18 months of age. Pneumocystis is transmitted from person to person by air. The disease probably manifests itself by a new acquisition of infection and/or the reactivation of a latent infection often leading to fatal pneumonia without treatment. Without control of cellular immunity, the pathogen actively replicates and obstructs and damages the pulmonary alveoli, causing death by asphyxiation.
R-DiaPnJTM kit is validated on geneLEAD VIII, MAgNAPure 96 and LightCycler 480 II systems from Roche designed to qualitatively detect Pneumocystis jirovecii in biological samples (bronchoalveolar lavages) collected from patients showing symptoms related to this pathogen using real-time PCR.