Clostridium difficile is a species of Gram positive bacteria of the genus Clostridium that causes diarrhea and other intestinal diseases when competing bacteria are wiped out by antibiotics. C. difficile is transmitted from person to person by the fecal-oral route. The organism forms heat-resistant spores that are not killed by alcohol-based hand cleansers or routine surface cleaning, thus, these spores survive in clinical environments for long periods. C. difficile may become established in the human colon (2–5% of the adult population). Sometimes antibiotic therapy for various infections has the adverse effect of disrupting the normal balance of the gut flora, in which case Clostridium difficile may opportunistically dominate, causing Clostridium difficile infection. Latent symptoms often mimic some flu-like symptoms. Often, it can be cured simply by discontinuing the responsible antibiotics.
G-DiaDiffTM is a trusted and easy-to-use molecular diagnostic CE-IVD kit designed to qualitatively detect Clostridium difficile (tcdA/tcdB) in biological samples (stool) collected from patients showing symptoms related to this pathogen using real-time PCR.